Thymosin Beta-4
Tissue repair and immune modulation
Overview
Thymosin Beta-4 (Tβ4) is the full-length 43-amino acid peptide from which TB-500 is derived. It is the most abundant actin-sequestering protein in the body and plays crucial roles in tissue development, repair, and immune function.
Mechanism of Action
Full-length actin regulation → complete tissue repair signaling cascade → promotes stem cell migration → enhances wound healing → modulates immune response → promotes cardiac repair after infarction.
Benefits
- Complete tissue repair
- Cardiac regeneration
- Hair follicle regeneration
- Corneal healing
- Immune modulation
- Neurological repair
Dosing Protocol
Half-Life
~2 hours
Duration of pharmacological activity after administration.
Side Effects
- Generally well-tolerated
- Mild fatigue
- Head rush
- Injection site reactions
Stacking Recommendations
Storage & Reconstitution
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 14 days.
Research Notes
Phase 2 trials for cardiac repair (RegeneRx). Studied for dry eye (Phase 3 complete). One of the most fundamental tissue repair molecules. TB-500 is a synthetic fragment with similar but more targeted activity.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.