NAD+
Cellular energy and cognitive function
Overview
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell. It is essential for energy metabolism, DNA repair, and cellular signaling. NAD+ levels decline significantly with age, contributing to age-related diseases.
Mechanism of Action
Essential cofactor for sirtuins (SIRT1-7) → activates PARPs for DNA repair → required for mitochondrial electron transport → regulates circadian rhythm → modulates inflammatory pathways via CD38.
Benefits
- Cellular energy restoration
- DNA repair enhancement
- Cognitive function support
- Anti-aging at cellular level
- Sirtuin activation
- Improved mitochondrial function
Dosing Protocol
Half-Life
~1–4 hours (IV); precursors vary
Duration of pharmacological activity after administration.
Side Effects
- Flushing (IV)
- Nausea
- Headache
- Chest tightness (rapid IV)
- GI discomfort (oral)
Stacking Recommendations
Storage & Reconstitution
IV solutions: use immediately. NMN/NR supplements: cool, dry place. Some products require refrigeration.
Research Notes
David Sinclair's research has popularized NAD+ supplementation. Multiple clinical trials ongoing for various age-related conditions. NMN and NR are the most common precursors. Decline begins around age 40.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.