MOTS-c
Mitochondrial peptide for metabolic health and exercise mimicry
Overview
MOTS-c is a mitochondrial-derived peptide encoded by the 12S rRNA gene. It functions as an exercise mimetic, activating AMPK and improving metabolic homeostasis. It represents a new class of mitochondrial signaling peptides.
Mechanism of Action
Activates AMPK pathway → increases glucose uptake → enhances fatty acid oxidation → improves mitochondrial function → acts as a retrograde signal from mitochondria to the nucleus.
Benefits
- Exercise mimetic effects
- Improved insulin sensitivity
- Enhanced fat oxidation
- Mitochondrial optimization
- Anti-aging metabolic support
Dosing Protocol
Half-Life
~4–6 hours
Duration of pharmacological activity after administration.
Side Effects
- Injection site reactions
- Mild fatigue initially
- Generally well-tolerated
Stacking Recommendations
Storage & Reconstitution
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 14 days.
Research Notes
Discovered in 2015 by Dr. Pinchas Cohen. Studies show improved glucose regulation and exercise capacity. Levels decline with age. Active research in metabolic disease and longevity.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.