LL-37
Antimicrobial peptide for wound healing
Overview
LL-37 is a cathelicidin antimicrobial peptide naturally produced by the human immune system. It serves dual roles: directly killing pathogens and modulating the immune response to promote wound healing and tissue repair.
Mechanism of Action
Disrupts microbial membranes → recruits immune cells → promotes angiogenesis → modulates inflammatory response → enhances wound closure → activates P2X7 receptor signaling.
Benefits
- Broad-spectrum antimicrobial
- Wound healing promotion
- Immune modulation
- Anti-biofilm activity
- Tissue repair
Dosing Protocol
Half-Life
~4–6 hours
Duration of pharmacological activity after administration.
Side Effects
- Injection site reactions
- Localized inflammation (expected)
- Pain at injection site
Stacking Recommendations
Storage & Reconstitution
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 14 days.
Research Notes
Critical component of innate immunity. Studies show effectiveness against antibiotic-resistant bacteria. Being researched for chronic wound treatment and Lyme disease. Vitamin D stimulates natural LL-37 production.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.