KPV
Anti-inflammatory gut peptide
Overview
KPV is a tripeptide (Lys-Pro-Val) derived from alpha-melanocyte-stimulating hormone (α-MSH). It is a potent anti-inflammatory peptide with specific benefits for gut health, making it valuable for inflammatory bowel conditions.
Mechanism of Action
Inhibits NF-κB inflammatory pathway → reduces pro-inflammatory cytokines → modulates mucosal immune response → promotes gut barrier integrity → enters cells and suppresses inflammatory gene expression.
Benefits
- Potent anti-inflammatory
- Gut healing and barrier repair
- Reduces IBD symptoms
- Mucosal immune modulation
- Oral bioavailability
Dosing Protocol
Half-Life
~2–4 hours
Duration of pharmacological activity after administration.
Side Effects
- Minimal reported effects
- Mild GI changes initially
- Very well-tolerated
Stacking Recommendations
Storage & Reconstitution
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 14 days.
Research Notes
Studies show significant reduction in colitis markers. Potential for IBD treatment. Being researched for Crohn disease and ulcerative colitis. Can be administered orally for gut-specific effects.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.