Ipamorelin
Selective growth hormone secretagogue
Overview
Ipamorelin is considered the gold standard GH secretagogue due to its selective GH release without significantly affecting cortisol, prolactin, or appetite. It provides clean GH stimulation with minimal side effects.
Mechanism of Action
Selectively activates GHS receptors → stimulates GH release without cortisol/prolactin spikes → preserves natural GH pulsatility → does not desensitize with prolonged use.
Benefits
- Clean GH release
- No cortisol increase
- No appetite stimulation
- Excellent safety profile
- Sustained efficacy without desensitization
Dosing Protocol
Half-Life
~2 hours
Duration of pharmacological activity after administration.
Side Effects
- Mild head rush
- Water retention (minimal)
- Generally very well-tolerated
Stacking Recommendations
Storage & Reconstitution
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 28 days.
Research Notes
Widely regarded as the safest GH secretagogue. No desensitization in long-term studies. Most commonly stacked with CJC-1295 for synergistic GH release.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.