IGF-1 LR3
Long-acting insulin-like growth factor for muscle growth
Overview
IGF-1 LR3 is a modified version of IGF-1 with an extended half-life. The LR3 modification prevents binding to IGF-binding proteins, keeping it active longer. It is one of the most potent anabolic peptides available.
Mechanism of Action
Binds IGF-1 receptors → activates PI3K/Akt pathway → stimulates protein synthesis → promotes muscle hyperplasia (new cell formation) → enhanced nutrient partitioning → resistance to IGFBP binding.
Benefits
- Potent muscle growth
- Promotes hyperplasia
- Enhanced recovery
- Increased protein synthesis
- Fat reduction
Dosing Protocol
Half-Life
~20–30 hours
Duration of pharmacological activity after administration.
Side Effects
- Hypoglycemia
- Joint pain
- Gut growth (long-term)
- Jaw/hand growth
- Water retention
Stacking Recommendations
Storage & Reconstitution
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 14 days. Very fragile—avoid agitation.
Research Notes
Potent anabolic with significant side effect profile. Used in research for muscle wasting conditions. Not for casual use. Hypoglycemia risk requires careful monitoring.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.