Ibutamoren (MK-677)
Oral growth hormone secretagogue
Overview
Ibutamoren (MK-677) is a non-peptide, orally active growth hormone secretagogue that mimics ghrelin. It stimulates sustained GH and IGF-1 elevation and is unique among GH secretagogues for its oral bioavailability.
Mechanism of Action
Mimics ghrelin at GHS-R1a receptor → sustained GH secretion → elevated IGF-1 for 24 hours → does not suppress natural GH axis → increases appetite via ghrelin pathway.
Benefits
- Oral administration
- Sustained 24-hour GH/IGF-1 elevation
- Improved sleep quality
- Increased bone density
- Preserved muscle mass
Dosing Protocol
Half-Life
~24 hours
Duration of pharmacological activity after administration.
Side Effects
- Increased appetite
- Water retention/edema
- Lethargy
- Elevated blood glucose
- Joint pain
Stacking Recommendations
Storage & Reconstitution
Store at room temperature. Protect from moisture and light. Capsule or liquid forms.
Research Notes
Phase 2 clinical trials completed. Long-term studies (2 years) showed sustained IGF-1 elevation and improved bone mineral density. Not FDA-approved. Widely available as research chemical.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.