Humanin
Mitochondrial peptide for longevity
Overview
Humanin is a 24-amino acid mitochondrial-derived peptide encoded by the 16S rRNA gene. It was discovered as a neuroprotective factor against Alzheimer disease and has since been found to have broad cytoprotective and anti-aging effects.
Mechanism of Action
Binds IGFBP-3 and BAX → anti-apoptotic signaling → activates STAT3 pathway → reduces oxidative stress → modulates insulin sensitivity → mitochondrial protection → interaction with formyl peptide receptor-like 1.
Benefits
- Cytoprotection
- Neuroprotection
- Anti-apoptotic
- Improved insulin sensitivity
- Cardiovascular protection
- Mitochondrial support
Dosing Protocol
Half-Life
~30 minutes (but cellular effects persist)
Duration of pharmacological activity after administration.
Side Effects
- Injection site reactions
- Limited human data
- Generally well-tolerated in studies
Stacking Recommendations
Storage & Reconstitution
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 7 days.
Research Notes
Discovered by Hashimoto et al. (2001). Levels decline with age and correlate with metabolic health. Studies show protection against Alzheimer disease, atherosclerosis, and diabetes. Active research area.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.