FGL
NCAM-derived peptide for memory and neuroprotection
Overview
FGL (FG Loop) is a synthetic peptide derived from the neural cell adhesion molecule (NCAM). It mimics the interaction between NCAM and the FGF receptor, promoting neuroprotection and cognitive enhancement through neurotrophic signaling.
Mechanism of Action
Activates FGFR signaling pathway → promotes neuronal survival → enhances long-term potentiation → increases synaptic plasticity → modulates MAPK and PI3K pathways → anti-inflammatory in CNS.
Benefits
- Memory enhancement
- Neuroprotection
- Synaptic plasticity improvement
- Anti-neuroinflammatory
- Cognitive recovery
Dosing Protocol
Half-Life
~6–8 hours
Duration of pharmacological activity after administration.
Side Effects
- Injection site reactions
- Headache (rare)
- Limited human safety data
Stacking Recommendations
Storage & Reconstitution
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 14 days.
Research Notes
Preclinical studies show significant improvements in spatial memory and neuroprotection. Published research from Bhatt et al. and Bhatt & Bhatt. No human clinical trials. Promising target for cognitive disorders.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.