Dihexa
BDNF amplifier for cognitive enhancement
Overview
Dihexa is a synthetic hexapeptide derived from angiotensin IV, developed at Washington State University. It is reportedly 10 million times more potent than BDNF at promoting neuronal connectivity and has shown remarkable cognitive enhancement in animal studies.
Mechanism of Action
Activates hepatocyte growth factor (HGF/c-Met) signaling → promotes synaptogenesis → enhances dendritic spine formation → 10^7 times more potent than BDNF → crosses blood-brain barrier → promotes neuronal connectivity.
Benefits
- Extreme cognitive enhancement
- Synapse formation
- Memory improvement
- Potential Alzheimer treatment
- Neuronal connectivity
Dosing Protocol
Half-Life
~12 hours (estimated)
Duration of pharmacological activity after administration.
Side Effects
- Limited human safety data
- Potential overstimulation
- Anxiety (high doses)
- Use with extreme caution
Stacking Recommendations
Storage & Reconstitution
Store at room temperature or refrigerate. Protect from light.
Research Notes
Showed reversal of cognitive deficits in animal models of Alzheimer disease. Published by Harding et al. (2014). Extremely potent. No human clinical trials. Purely experimental compound.
Medical Disclaimer
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. Peptide therapy should only be initiated under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your physician before starting any new therapy. Regulatory status varies by jurisdiction.